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Sulfates are the foremost circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The first oxidative metabolite is two-hydroxy ethinyl estradiol, formed from the CYP3A4 isoform of cytochrome P450. Element of the 1st-move metabolism of ethinyl estradiol is thought to arise in gastrointestinal mucosa. Ethinyl estradiol may